Mucins in Infection and Inflammation

Grant number: 543704 | Funding period: 2009 - 2011

Completed

Abstract

Mucosal tissues, such as the gastrointestinal and respiratory tracts, are the most common site of infectious disease. We have found that the cells in these tissues produce molecules on their surface, known as mucins, that protect from infection. In the case of chronic infection the mucins prevent the inflammation that underlies the development of cancer. In this project we will be exploring the mechanisms by which mucins prevent infection and inflammation.

Related publications (5)

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MUC1 and MUC13 differentially regulate epithelial inflammation in response to inflammatory and infectious stimuli

YH Sheng, S Triyana, R Wang, I Das, K Gerloff, TH Florin, P Sutton, MA McGuckin

2013-01-01

The MUC1 cell-surface mucin is highly expressed on the gastric mucosal surface, while MUC13 is highly expressed on the intestinal ..

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The MUC13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis

YH Sheng, R Lourie, SK Lindén, PL Jeffery, D Roche, TV Tran, CW Png, N Waterhouse, P Sutton, THJ Florin, MA McGuckin

2011-12-01

Background and Aims: The MUC13 transmembrane mucin is highly and constitutively expressed in the small and large intestine. Althou..

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Localized suppression of inflammation at sites of Helicobacter pylori colonization

AL Every, GZ Ng, CD Skene, SN Harbour, AK Walduck, MA McGuckin, P Sutton

2011-10-01

While gastric adenocarcinoma is the most serious consequence of Helicobacter pylori infection, not all infected persons develop th..

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Mucin dynamics and enteric pathogens

MA McGuckin, SK Lindén, P Sutton, TH Florin

2011-04-01

The extracellular secreted mucus and the cell surface glycocalyx prevent infection by the vast numbers of microorganisms that live..

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Increased Helicobacter felis colonization in male 129/Sv mice fails to suppress gastritis.

G Ng, A Every, M McGuckin, P Sutton

2011-01-01

Development of the pathologies associated with Helicobacter pylori infection, most seriously gastric adenocarcinoma, are a consequ..

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